Vitamin B6/Nutrient Depletion:
- Amino acidsAmino acids: In humans, vitamin B6 decreased plasma levels of the amino acids tyrosine and methionine during endurance exercise (92).
- AntiasthmaticsAntiasthmatics: Theophylline, a prescription drug used to help manage asthma, has been shown to lower pyridoxine levels (59; 60).
- AntibioticsAntibiotics: According to secondary sources, destruction of gastrointestinal flora may reduce the production of vitamin B6.
- CycloserineCycloserine: Cycloserine, an antibiotic prescribed for tuberculosis, may affect the metabolism of pyridoxine (73).
- FurosemideFurosemide: In humans, furosemide increased urinary excretion of vitamin B6 (74).
- GlucoseGlucose: In human research, 100mg of pyridoxine daily improved glucose metabolism in gestational diabetes (28; 29).
- Hormonal agentsHormonal agents: The need for vitamin B6 supplementation in women taking birth control pills has not been proven, although some studies show decreased pyridoxine levels in these women (78).
- HydrazinesHydrazines: Pyridoxal-5-phosphate plasma concentrations were depressed in children receiving tuberculosis chemotherapy including isoniazid (81). Based on a case report, pyridoxine is suggested following isoniazid overdose (82). Hydralazine (Apresoline®) can increase pyridoxine requirements (83). Phenelzine can increase pyridoxine requirements (84).
- LipidsLipids: In humans, vitamin B6 decreased plasma levels of free fatty acids during endurance exercise (92).
- Penicillamine (Cuprimine®, Depen®)Penicillamine (Cuprimine®, Depen®): According to secondary sources, penicillamine may reduce plasma levels of vitamin B6.
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The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.